Dr. Umesh Khot is the Vice-Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine at the Cleveland Clinic and the author of a research letter in the New England Journal of Medicine examining the effects of the astronomical price increases of isoproteronol and nitroprusside. In this doc-to-doc interview, Dr. Khot discusses the reasons the prices increased, the effects that had on utilization of the drugs, and the implications this has more broadly in our healthcare system.